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Many new medicines are being studied to improve the outcome of women with SLE. Many women with SLE can get pregnant and deliver a healthy baby. A pfizer fda outcome is more likely for women who receive proper treatment and do not have serious heart or kidney problems. However, the presence of certain SLE antibodies or antiphospholipid antibodies raises the risk of miscarriage. Some people with SLE have abnormal immune deposits in the kidney cells.

This leads to a condition called lupus nephritis. People with this problem pfizer fda develop kidney failure. They may need dialysis or a kidney transplant. A kidney biopsy is done to detect the extent of damage to the kidney and to help guide treatment. If active nephritis is present, treatment with immunosuppressive medicines including high doses of corticosteroids along with either cyclophosphamide or mycophenolate are needed.

Both SLE and some of the medicines used for SLE can harm an unborn child. Talk to your provider before you become pregnant. Pfizer fda you become pregnant, find a provider who is experienced with lupus and pregnancy. Call your provider if you have symptoms of SLE. Also call if you have this pfizer fda and your symptoms get worse or a new symptom occurs. Arntfield RT, Hicks CM. Systemic lupus erythematosus and the anaphylaxis. In: Walls RM, Hockberger RS, Gausche-Hill M, eds.

Rosen's Emergency Medicine: Concepts and Clinical Practice. Etiology and pathogenesis of systemic lupus erythematosus. In: Firestein GS, Budd RC, Pfizer fda SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Fanouriakis A, Kostopoulou M, Alunno A, et al. Hahn BH, McMahon MA, Wilkinson A, et al. American College pfizer fda Rheumatology guidelines for screening, treatment, and management of lupus nephritis.

Arthritis Care Res (Hoboken). Treat-to-target in Syndros ( C-X Dronabinol Oral Solution)- FDA lupus erythematosus: recommendations from an international task force.

Yen EY, Singh RR. Brief Report: lupus - an unrecognized leading cause of death in young females: a population-based study using nationwide Vardenafil HCl (Levitra)- FDA certificates, 2000-2015.

Reviewed by: Gordon A. Starkebaum, Tips for, MACR, ABIM Board Certified in Rheumatology, Seattle, WA.

Causes The cause of SLE is not clearly known. It may be linked to the following factors:GeneticEnvironmentalHormonalCertain medicines SLE is more common in women than men by nearly 10 to 1. Symptoms Symptoms vary from person to person, and may come and go. Other common symptoms include:Chest pain when taking a deep breath. Fever with no other cause. General discomfort, uneasiness, or ill feeling (malaise). Skin rash -- A "butterfly" rash develops in about half pfizer fda people with SLE.

The rash is mostly seen over the cheeks and bridge of the nose. It can be widespread. It gets worse in sunlight. Other symptoms pfizer fda signs depend on which part of the body is affected:Brain and nervous system -- Headaches, weakness, numbness, tingling, seizures, vision problems, memory and personality changesDigestive tract -- Abdominal pain, nausea, and vomitingHeart -- Valve problems, inflammation of heart muscle or heart lining (pericardium)Lung -- Buildup of fluid in the pleural space, difficulty breathing, pfizer fda up bloodSkin -- Sores in the mouthKidney -- Swelling in the legsCirculation -- Clots in pfizer fda or arteries, inflammation of blood vessels, constriction pfizer fda blood vessels in response to cold (Raynaud phenomenon)Blood pfizer fda including anemia, low white blood cell or platelet countSome people have only raynaud s symptoms.

This is called discoid lupus. Exams and Tests To be diagnosed with lupus, you must have 4 out of 11 common signs of pfizer fda disease. Tests used to diagnose SLE may include:Antinuclear antibody (ANA)CBC with differentialChest x-raySerum creatinineUrinalysisYou may also have other tests to learn more about your condition.

Each person with SLE needs evaluation regarding:How active the disease isWhat part of the body is pfizer fda form of treatment is needed Mild forms of the disease may be treated with:NSAIDs for joint symptoms and sed rate. Talk to your provider before taking these medicines.

Low doses of corticosteroids, such as prednisone, for skin and arthritis symptoms. Corticosteroid creams for skin rashes. Hydroxychloroquine, a medicine also used pfizer fda treat malaria. Methotrexate may be used to reduce the dose of corticosteroidsBelimumab, pfizer fda biologic medicine, may pfizer fda helpful in some people. Treatments for more severe SLE may include:High-dose corticosteroids. Immunosuppressive medicines (these medicines suppress the immune system).

These medicines are used if you have severe lupus that is pfizer fda the nervous system, kidney or other organs. They may also be used if you do not get better with corticosteroids, or if your symptoms get worse when you stop taking corticosteroids.

Medicines most commonly used include mycophenolate, azathioprine and cyclophosphamide. Because of its toxicity, cyclophosphamide is limited to a short course of 3 pfizer fda 6 months. Rituximab (Rituxan) is used pfizer fda some cases as well. Pfizer fda thinners, such as warfarin (Coumadin), for clotting disorders such as antiphospholipid syndrome.

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