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Survivors of childhood ALL are at increased risk of later developing other types of cancers, including brain and spinal cord tumors, basal Daytrana (Methylphenidate Transdermal)- Multum skin carcinoma, and myeloid (bone marrow) malignancies.

Radiation and older Daytrana (Methylphenidate Transdermal)- Multum of chemotherapy are mainly responsible for this risk. Newer types of ALL treatment may be less likely to cause secondary cancers. Treatment During Remission (Consolidation and Maintenance) Consolidation and maintenance therapies follow induction and Daytrana (Methylphenidate Transdermal)- Multum remission.

Consolidation (Intensification) TherapyBecause there is a high risk of the cancer returning (relapsing) after the first phase of treatment (induction therapy), an additional course Daytrana (Methylphenidate Transdermal)- Multum treatment is given next. Examples of consolidation regimens for people at standard risk:A limited number pfizer advertising courses of intermediate- or high-dose methotrexate.

An anthracycline drug, such as daunorubicin (Cerubidine), used for reinduction followed by cyclophosphamide (Cytoxan, Neosar) 3 months qbrexza remission. Extended use of an asparaginase drug. Children may receive cyclophosphamide, low-dose cytarabine, and a thiopurine (mercaptopurine or thioguanine), followed by methotrexate. More intense regimens are used for people at high-risk for relapse. MaintenanceThe last phase of treatment available maintenance (also called continuation therapy):Maintenance therapy typically uses weekly administration of methotrexate (usually in oral form) and daily doses of mercaptopurine.

If CNS prophylaxis was not given before, it may be given now. Vincristine and a corticosteroid drug (generally dexamethasone) may be added to standard maintenance therapy.

Treatment After Relapse Relapse is when cancer returns after remission. The following are factors that increase the risk for relapse after initial treatments:Microscopic evidence of leukemia Daytrana (Methylphenidate Transdermal)- Multum 20 weeks of therapy (minimal disease). A high age blood cell count at the time of diagnosis.

Disease that has spread beyond the bone marrow to other organs. Certain genetic abnormalities, such as the presence of the Philadelphia Daytrana (Methylphenidate Transdermal)- Multum. People with high disease levels after 7 to 14 days of induction therapy. The need for 4 or more weeks of induction chemotherapy in order to achieve a first complete remission. The decision depends on a number of factors including how soon relapse occurs after treatment:Children who relapse 3 or more years after achieving a first complete remission usually achieve a second remission with a second round of standard chemotherapy treatments.

Children who relapse within 6 months to 3 years following treatment may be able to achieve remission with a more aggressive course of chemotherapy. Children who relapse less than 6 months following initial treatment, or while Daytrana (Methylphenidate Transdermal)- Multum chemotherapy have a lower chance for a second remission. In such cases, stem cell transplantation may be considered. Stem cell transplantation is especially considered for children who relapse with T-cell ALL.

Adults with ALL who experience a relapse following maintenance therapy are unlikely to be helped by additional chemotherapy alone. They are considered candidates for stem cell transplantation. Stem cell transplantation is also an option for adults, but not children, who have achieved a first remission. Chemotherapy and Other Drugs Used After RelapseMany different types of drugs are used to treat ALL relapses.

Transplantation TransplantationStem cells that are made in the bone marrow are the early form of all blood cells in the body. Types of DonorsThe stem cells to be given to the person with leukemia can come from either the patient (autologous) or a donor (allogeneic):Allogeneic transplant. In an allogeneic transplant, the stem cells are taken from another person or donor. The immune system of the person receiving the new cells will usually try to reject these new, foreign cells.

The more the donor johnson 360 are genetically similar, the less likely the person receiving the cells will reject them.

Allogeneic transplants that are from genetically matched sibling donors offer the best results in ALL.



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